From the treatment point of view many drugs have been tried with various
efficacyin visceral leishmaniasis.Objectives:The study was undertaken to
compare the efficacy of intravenous amphotericin B and oral miltefosine in the
treatment of visceral leishmaniasis in children. Materials and methods: In this
study 60 consecutive diagnosed cases of kalaazar were studied in pediatric
indoor ward of J.L.N. Medical College & Hospital Bhagalpur. All thecases
included in study, randomly divided into two groups A and B with equal no. of
patients ( 30 in each ) in both groups. Patients of group A were given
intravenous Amphotericin B in the dose schedule of 1mg/kgon alternate day for
15 doses. Patients of group B were given oral miltefosine in dose schedule of
2.5mg /kg daily for 28 days.During the therapy, clinical and parasitological
response and safety profiles of the drugs in both groups were closely
monitored. Conclusion: ? Both the drugs i.e. Amphotericin B as well as
Miltefosine had been observed as equally efficacious in causing clinical as
well as parasitological cure in pediatric cases of visceral leishmaniasis and
no sufficient toxicity developed in either group and so they are equally safe
in children ? - See more at:
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