Background:-
Diabetes mellitus (DM) is a metabolic disorder characterised by chronic high
blood glucose levels with disturbance of carbohydrate, fat and protein
metabolism resulting from defects in insulin secretion, insulin resistance or
both. The global prevalence of DM among adults aged 20?79years would increase
from 6.4% (affecting 285 million adults) in 2010 to 7.7% (439 million adults)
by 2030. From year 2010 to 2030, there would be a 69% increase in numbers of
adults with DM in developing countries and a 20% increase in developed
countries. Studies by (Porapakkham et al.,2008) and (Margaret et al.,2013) the
proportions of population affected by DM were increasing inthe countries, which
have higher proportion of ageing societies. The prevalence of diabetes was
lowest (8.5%) in the 30?39age group and increased steadily with age to 22.7%
for those who were more than 60 years old. Therefore, the burden due to DM is
likely to rise steadily in because of population ageing Results:- Of all
patients the percentage of type 1 DM was 35.5% and type 2DM was 64.5% Of all
the patients with DM, 56.4% reported the use of oral hypoglycemic
agents,(43.6%) insulin with or without combination therapy Assessment of
medical history showed that 18.6% of patients had hypertension , 9.6% of
patients had dyslipidemia , 8.5% of patients had liver disease (50% fatty liver
-20% hepatitis c positive - and10% cirrhosis) ,4.3% of patients had
hypothyrodism .and 59% has no association Conclusion:- the proportion of
patients with poor glycemic control was high, which is nearly comparable to
that reported from many countries. Longer duration of diabetes, and not
adherent to diabetes selfcare management behaviors were associated with poor
glycemic control. An educational program that emphasizes lifestyle modification
with importance of adherence to treatment regimen would be of great benefit in
poor glycemiccontrol see more
Saturday, 30 April 2016
RELATION BETWEEN AGE AT MENOPAUSE, REPRODUCTIVE LIFE SPAN AND TYPE 2 DIABETES. - See more at: http://www.journalijar.com/article/8221/relation-between-age-at-menopause,-reproductive-life-span-and-type-2-diabetes./#sthash.Bh0hyfMr.dpuf
: Background: The aims of this study are to (1) shed light on
the temporal relation between development of menopause and development of type
2 diabetes. (2) Clarify whether early menopause and short reproductive life
span could be considered as novel risk factor for type 2 diabetes. (3) Decide
whether type 2 diabetes is to be considered a cause and /or a sequel of early
menopause and short reproductive life span. Subjects and Methods: This study
was conducted on four hundred post menopausal women. Their ages? range was
(40-87y) with average mean (59.28?9.01y), a questionnaire was done to every
subject including reproductive factors, baseline characteristics, and
laboratory investigations. Results: our study was on postmenopausal women.
Their ages at menopause were (31-63) with mean average (47.73?5.02). The
prevalence of diabetes in post menopausal women was 38%. There was a
significant association between hyperglycemia and duration of menopausal status
after adjustment for age and other risk factors of diabetes with p < .001
& OR 1.04 . But no association was found between neither age at menopause
nor reproductive life span and the development of diabetes with p value 0.56,
0.92 respectively. There was a significant association between waist
circumference and risk of developing diabetes in post menopausal women with p
value .009 & OR .001. No significant association between hysterectomy and
risk of type 2 diabetes with p value 1. There was no significant association
between HRT & diabetes with p value .6. However, there was a significant
association between OCP and the risk of diabetes with p value .02 .There was a
significant association between gravidity and risk of diabetes with p .002 but
not with parity with p value .16. Conclusion: There was association between the
duration of menopause and development of type 2 diabetes. Waist circumference
representing central adipose tissue playing the major role in risk of diabetes
in postmenopausal women. - See more at:
Reefs and Scleractinian Community to Open Islands the South China Sea of Vietnam. - See more at: http://www.journalijar.com/article/8215/reefs-and-scleractinian-community-to-open-islands-the-south-china-sea-of-vietnam./#sthash.BNMDQCTL.dpuf
Studied
reefs and coral community of open islands South China Sea of South Vietnam.
Differences in the structure and composition of reef communities depending on
the morphology of coastal slopes. Shows a rich diversity of corals, more than
200 species and their high degree of similarity with a wealth of hermatypic
Scleractinia on other reefs of Vietnam and in general with the reefs of the
South-Western Pacific. - See more at:
Expression and prognostic impact of caspase 8 associated protein 2 (CASP8AP2) in childhood acute lymphoblastic leukemia. - See more at: http://www.journalijar.com/article/8214/expression-and-prognostic-impact-of-caspase-8-associated-protein-2-(casp8ap2)-in-childhood-acute-lymphoblastic-leukemia./#sthash.xhQ3lXTR.dpuf
Objective: To measure the expression level of
caspase 8 associated protein 2 (CASP8AP2) in newly diagnosed bone marrow
childhood acute lymphoblastic leukemia (ALL) samples and analyze its
associations with bone marrow relapse, disease free survival (DFS) as well as
overall survival (OS). Materials and Methods: Fifty newly diagnosed ALL cases
were evaluated using clinical and laboratory measures. CASP8AP2 expression was
measured in bone marrow samples using real-time quantitative PCR (qRT-PCR).
Another 25 blood samples from healthy reference control subjects with matched
age and sex were also measured for CASP8AP2 expression. Results: Patients with
high CASP8AP2 expression have significantly better OS (p value = 0.017) and DFS
(p value = 0.018) than those with low CASP8AP2 expression. There was a significantly
high bone marrow relapse rate in CASP8AP2 low-expression group with (p value =
0.018). From receiver operating characteristic (ROC) curve, the best cut-off
values were established for CASP8AP2 for the prediction of development of
relapse in the present study group was 0.319, with a sensitivity of 100% and a
specificity of 91.3%. The area under the curve was 0.916. Conclusion: Relapse
showed statistically low CASP8AP2 expression versus those who continued
complete remission (CCR). So, CASP8AP2 expression was reported as an
independent prognostic factor in childhood ALL. - See more at:
INFLUENCE OF ENOLOGICAL TREATMENTS ON DISSOLVED OXYGEN CONTENT OF MOROCCAN RED WINE - See more at: http://www.journalijar.com/article/8193/influence-of-enological-treatments-on-dissolved-oxygen-content-of-moroccan-red-wine/#sthash.1FpLHZqn.dpuf
The aim of this study is to investigate the impact of different
technological operations on dissolved oxygen amount. The concentration of
oxygen is measured before and after different operations (ranking, earth
filtration, tangential filtration, cadridgue filtration, and bottling) in
cellar IQQDAR of company LES CELLIERES DE MEKNES, Morroco. It showed that all
treatment increase significantly (p<0, 05) the dissolved oxygen amount in
the red wine. The greatest increase has been observed during ranking (reception
of wine) and bottling of wine, 1,81 and 2,7 mg/L,respectively. - See more at:
STRUCTURE AND FUNCTION OF MULTIDRUG TRANSPORTER PROTEINS AND MECHANISM OF RESISTANCE TO AVAILABLE CHEMOTHERAPY. - See more at: http://www.journalijar.com/article/8175/structure-and-function-of-multidrug-transporter-proteins-and-mechanism-of-resistance-to-available-chemotherapy./#sthash.Ba1u1p5q.dpuf
Simple prokaryotic cells and complex eukaryotic
cells constantly monitor their environment and try to maintain the chemical
homeostasis and composition inside their cells? liquid broth (cytoplasm). Cells
express, on or across their lipid-bilayer membrane, various proteinaceous
receptors, in order to communicate with extra-cellular matrix system by
exchange of nutrients, ions, solutes and other molecules of diverse nature and
polarity. Majority of compounds, including natural toxins or drugs, can move in
or out of cell via passive transport depending on the permeability of membrane
by either simple diffusion (through protein-lined channel), facilitated
diffusion (using carrier proteins) or osmosis (through membrane) based on their
small size, polarity and concentration gradient across the membrane. Whereas,
the remaining category of compounds - mainly toxins, metabolites and xenobiotic
- which cells sense as poisonous, harmful and unwanted is transported out of
the cell through specialized membrane transporters at the expense of energy
molecules, called Adenosine Tri-Phosphate (ATP), as they do not follow the
normal mechanism of transport. These membrane proteins have evolved as a
multidrug transporter, which belongs to the superfamily of ATP-binding cassette
(ABC) transporters, are able to expel a wide range of substrates from cells
assisted by ATP hydrolysis. These proteins are responsible for efflux of
antimicrobials and anticancer drugs out of their target cells? membrane
rendering therapy ineffective and development of resistance to available drugs.
Understanding the structure, function and mechanism of these proteins holds the
key to designing and develop right drug and therapy to combat the problem of
drug resistance. - See more at:
ELECTROLYTE DISTURBANCES IN CRITICALLY ILL PATIENTS.
Background:- Critically ill child is any
child needs supportive treatment for its biological function either by drugs or
mechanical ventilation & supportive treatment by drugs or mechanical
ventilators. Demographic Data were collectedØis usually associated by disturbances in Electrolytes
due to different associated factors. Objective:- The aim of our work is to
measuring level of sodium, potassium, and calcium, in critically ill patient
Methods:- The study was conducted at pediatric Intensive Care Units ( PICUS )
of the Pediatric Department, Benha University Hospitals during the period from
February 2015 to April 2015, on females and males equally from 1month to 18
years needing & Full examination was
done and Blood samples were taken to do Complete blood count, C-reactive
protein, Liver function test, Kidney function test, Arterial blood gases &
serum electrolytes as serum Ca, Na & K level. Results:- Hypocalcemia is
more common in our PCIU 71.7% of cases with PRISM score mean of (23.0?11.42
(5-47) ) with Death prediction of (39.07?23.51 (9-75)), Hypercalcemia is less
common 2.5% of cases with PRISM score mean of (43.67?1.53(42-45)) & Death
prediction of (75.0?0.0 (75-75) ), Hypokalemia is more common 38.8% of cases
with PRISM score of (25.04?8.21 (8-38) ) and Death prediction of (44.52?20.49
(9-75) ), Hyperkalemia is less common 22.5% of cases with PRISM score of
(27.44?13.58 (10-47)) and Death prediction of (47.22?24.91 (15-75)), Na level
of no significance relation with critically ill children. Conclusion:-
Critically ill children, hypocalcemia& hypokalemia are more common among
children but hyperkalemia & hypercalcemia are associated with high level of
PRISM score & Death Prediction see more.
Morphological and histological study of the stomach in local rodent species(guinea pig) Cavia porcellus
The study of stomach in adult male local guinea
pigs rodents included the morphological description ,histometric measurments
and histoarchitecture at the light microscope level by using Haematoxyline and
Eosine stain methods. The results revealed that the stomach had C shaped with the
presence of two curvatures and shallow angular notch. It is simple (unilocular)
smooth and homogenous grossly without external demarcation limiting ridge
(margo plicatus) between its devisions , white grayish in color and slightly
transparent. Blood was supplied to the stomach by the coeliacomesentric trunk.
The microscopic examination revealed that the wall of the stomach show the
characteristic four compartmant tunics : Mucosa , Submucosa , Muscularis
externa and Serosa.The stomach regions were cardiac type (A, B) , fundic and
pyloric .The mean thickness of tunica mucosa was the maximum in fundic region
(110+10) and the minimum in cardiac region type A (13 + 2.7386). The mean
thickness of tunica muscularis externa was the maximum in pyloric region (67+
4.4721) and the minimum in cardiac region type A(29.6 + 0.5477). Non
keratinized stratified squamous epithelium covers the tunica mucosa of cardiac
region type A with visible stratum granulosum , while Simple columnar
epithelium with gastric glands and pits covers the tunica mucosa of the other
regions of stomach . Skeletal and smooth muscle fibers found in tunica
muscularis externa of cardiac region type A ,while spiral ,circular and
longitudinal arrangement of smooth muscle fibers found in tunica muscularis
externa of the other regions of stomach. The simple tubular cardiac glands
composed of predominate mucous secreting cells , mucous acinar cells found on
the basal surfaces , few parietal cells, enteroendocrine cells and
undifferenciated cells. The simple tubular fundic glands with shallow pits
composed of mucous neck cells, parietal cells which were predominantly present
in the upper and lower half of the fundic glands , chief cells and
enteroendocrine cells that found in the lower third of each fundic glands. The
long simple branched tubular pyloric glands with deep pits, composed of
predominantly mucous acinar cells along the leng of the frontal and basal
surfaces , randomly parietal cells,few chief cells and enteroendocrine cells. -See more at:
BIODIVERSITY, DISTRIBUTION AND MORPHOLOGICAL CHARACTERIZATION OF MUSHROOMS IN THE SOUTH WESTERN REGION OF BANGLADESH
The south western region of Bangladesh is known
as mangrove forest region, positioning at 22?55\'N latitude and 89?15\'E
longitudes having a wide range of ecosystem. The present survey was conducted
to record the biodiversity, distribution and morphological characterization of
mushrooms of south western region of Bangladesh. The survey was conducted from
June to October, 2014 in 5 districts namely Kushtia, Chuadanga, Jessore,
Satkhira and Khulna. A total of 16 mushroom species belong to 10 genera, under
8 families were recorded during the survey. Lepiota cristata was found
abundantly in the survey areas among the other collected species and it
exhibited the maximum frequency of occurrence (25%), whereas the maximum
density (13.51%) was recorded for Hypholoma fasciculeare and Coprinellus
micaceus, followed by Lepiota cristata, Coprinus comatus and Mycena
californiensis (10.81%). Furthermore, the density of Gymnopilus purpuratus,
Coprinus sterquilinus, Marasmius oreades, Hypholoma capnoides and Coprinellus
plagioporus were recorded as 8.10%. Moreover, Lepiota cristata was distributed
in Daulatpur of Kushtia and Koira of Khulna districts in the south western
region of Bangladesh. This is the first report of macro fungi biodiversity and
their distribution in the south western region of Bangladesh. - See more at:http://www.journalijar.com/uploads/526_IJAR-8886.pdf
IMPACT OF COMPACTION AND BLASTING ACTIVITY ON LIVESTOCK DURING CONSTRUCTION OF STANDARD GAUGE RAILWAY IN MAKINDU-KIBOKO AREA OF MAKUENI COUNTY, KENYA. - See more at: http://www.journalijar.com/article/8073/impact-of-compaction-and-blasting-activity-on-livestock-during-construction-of-standard-gauge-railway-in-makindu-kiboko-area-of-makueni-county,-kenya./#sthash.YCbJhf7q.dpuf
The study aimed to identify effects of railway
construction activities on livestock during construction of Mombasa-Nairobi
Standard Gauge railway at Makindu-Kiboko area. Purposive sampling method was
used; all households within 0-200 meters on either side of the railway line and
blasting site who reported an effect associated with railway construction
activities were interviewed. Out of 169 households interviewed, only 25 (15%)
reported effects to their livestock. Construction activities like blasting rocks
and soil compaction resulted in ground vibrations, noise and dust that were
harmful to livestock and vegetation. About 14% and 8% reported mortalities in
chicken and goats respectively. About 2% reported failure of eggs to hatch.
Dust resulted in crop and pasture loss in addition to health effects on
livestock. Noise pollution and cracks on buildings were also reported. In
conclusion, construction activities like rock blasting and soil compaction have
negative effects on livestock health in addition to crop and pasture losses and
mitigation measures need to be put in place before such an undertaking is
commenced - See more at:
Sunday, 24 April 2016
Effect of Salt Stress on Germination and Growth of T. foenumgraecum Seedlings
Seedling establishment is a critical stage that determines
production of crop at later stages, thus it necessitates studying the impact of
salt stress at primary level. Present study is aimed to evaluate the effect of
salinity stress on germination as well as growth of seedlings of T.
foenumgraecum. Seedling germination showed 100% germination of seeds upto 100mM
NaCl treatment but beyond it there is a sharp decline in germination percentage
as it showed 60% decline in 200mM NaCl added set. Salt stress at higher
salinity levels (beyond 100mM NaCl) also resulted in delayed seedling
germination. Results showed there is not much variation in 50 and 100mM NaCl
treatments in comparison to control. But it shows strong inhibition in terms of
length as well as fresh weight of different plant parts as cotyledon,
hypocotyls as well as roots of seedlings with increasing level of salt solution
particularly at higher salt treatments as 150 and 200mM NaCl treatments. This
decline was more prominent in roots (71.43% and 73.47%) then in shoots (54.8%
and 55.06%) and least in cotyledons (21.87% and 19.51%) in comparison to
control in 7 and 15 days old fenugreek seedlings. The increasing salt concentrations
increase the phytotoxicity of shoot and root and decrease the tolerance indices
and the seedling vigor indices - See more at:
PHYSIOLOGICAL AND HISTOLOGICAL STUDY OF EXPERIMENTAL DIABETES MELLITUS BY ALLOXAN. -
Study included using exogenous alloxan (100 mg
for every 1 kg of animal weight) for inducing experimental diabetes mellitus in
rats. 46 rats divided for two groups, during the time of study glucose,
glycogen levels estimated every week extend for 3 weeks. Also the study
included histo-pathological effect on liver and pancreas. The experiment showed
an increase in blood glucose, after 7 days, 14 days, 21 days of alloxan
injection, values were (11,92 ), (15,89), (17,31) mmol/Lrespectively, glucose
level of control group was (5.84 - 7.44 mmol/L). while glycogen level in
liverat the same period was (0,72 ), (018), (0.075) mg/g. Control group
glycogen was (3,18 ? 3.65mg/g) during 3 weeks of experiment. Histological
examination of liver samples of ratswere traced pronounced signs of toxic
hepatitis as a violation of the beam structure of the lobules, necrosis of
hepatocytes, fat and protein dystrophy, the presence of infiltration of
hematogenous cell clusters. In the control group was characterized by a uniform
distribution with respect to the same hepatocytes for liver slices, hepatocytes
and the structure of the test cells corresponded to the ratio of the classical
histological characteristics of the active functioning of the liver. The number
of β-cells in the islets of sharply reduced, in most of them marked
vacuolization of the cytoplasm, reducing the size of the nuclei, chromatin
condensation, in some cells - kariopik?noz. Presence of a lymphocytic
infiltrate along the periphery of the islets, interlobular connective tissue
edema, congestion of the capillaries; vascular stasis traced. - See more at:
Saturday, 23 April 2016
VALMIK [MADURA FOOT,MYCETOMA,ACTINOMYCOSIS] ? A CASE STUDY.
Ayurveda is the traditional life & medical
science of India, which is being accepted globally. Basic theme of Ayurvda is
to maintain health, prevent disease and if becomes ill, treat the disease. In
routine practise, we come across with many conditions where other system of
medicine are failed to overcome, and the conditions are cured by Ayurveda
without side effects, complications and recurrences, Madura foot[myocytoma
pedis] is one of them. It is long standing skin condition of fungal origin seen
in migrated individuals affecting foot. It can be correlated as Valmik
described in Ayurveda as kshudra roga[minor disease of skin]. Many times modern
medical science cannot give complete cure, in such cases Ayurvedic therap
,particularly Raktamokshan [leech application]is definitely beneficial .Though
it is so ,our experimental observations go in favour of integrated approach. -
See more at:
CHRONIC IMMUNE THROMBOCYTOPENIA AND HELICOBACTER PYLORI INFECTION IN SUDANESE PATIENTS. -
Background/Aim: Immune thrombocytopenia (ITP) is an
autoimmune disease mediated by anti-platelet auto-antibodies. There is growing
evidence that the eradication of H. pylori effectively increases platelet count
in a considerable proportion of H.pylori- infected ITP patients. The study
aimed to determine sero-prevalence of H. pylori in chronic ITP patients and to
compare the ITP characteristics in H.pylori infected and non-infected ITP
patients. Patients/Method: the study was done on 60 already diagnosed ITP
patients of at least 6|12 duration. On all patients were done Complete blood
count (CBC), blood cells morphology (thin film), IgG for H.pylori antibodies
and anti-platelet antibodies by ELISA. Anti-lewis antibodies were done by a
serological method. All patients were screened for hepatitis B, C and HIV by
ICT. The initial platelets count at diagnosis was obtained from the patients
note and bone marrow examination performed by consultant hematologist. Their
ages ranged between 2-74 years, there were 21 males and 39 females. 57 patients
already were underwent corticosteroids treatment. Results: Anti H.pylori IgG,
Anti-platelets, and anti-Lewis abs were detected in 63%, 58%, and 28%,
respectively. There was a significant difference between platelets count at time
of diagnosis and time of enrolling, P: < .00001. Moreover, a significant
difference was found in platelets count at time of enrolling between H. pylori
sero-positive and sero-negative ITP patients, P: 0.00006. In ITP treated
patients (57/60) there was a significant rise in platelets count after compared
to the initial count, P: 0.00001. In comparison of ITP characteristic between
H.pylori sero-positive and sero-negative ITP patient; there was a significant
difference in regard to anti-platelets antibodies status, P: 0.0001, platelets
count at time of enrolling P: 0.00006, and corticosteroid response, P: 0.01.
Conclusion: Anti -H.pylori and anti-platelets antibodies were frequent in ITP
patients. Reduction in the platelet count was observed in H.pylori sero-positive
ITP patients than sero-negative ones. In the majority of H.pylori sero-positive
ITP patients; thrombocytopenia still persists even in those patients who
underwent corticosteroids treatment - See more
VITAMIN D3 LEVELS IN DIABETES MELLITUS AND ITS CORRELATION WITH HbA1C LEVELS.
Background- Vitamin D3
is known for its calcium absorption and bone metabolism; but now been
recognized as an accessible predictor, risk factor and biomarker of type 2
diabetes mellitus (T2DM). Aim- The aim of the study is to determine serum
vitamin D3 levels in T2DM patients and ascertain its correlation with HbA1c.
Setting and design- This is a cross-sectional study through screening of
patients with T2DM attending the OPD/ indoor of SGRDIMSR, Amritsar. Material
and method- With prior informed consent, 100 diabetic patients were examined
for complications of diabetes and investigated for HbA1c, serum calcium and
vitamin D3 levels in addition to routine investigations. Vitamin D3 levels were
determined and relation with HbA1c levels was established. Results- Among the
100 T2DMpatients, 46% had deficiency, 22% had insufficiency and 32% had
sufficiency of vitamin D3. The mean HbA1c value was 7.74 ? 1.63% in vitamin D
sufficiency, 9.83 ? 2.02% in insufficiency, and 9.91 ? 2.5% in deficiency
making the correlation highly significant (p <0.0001). The fasting plasma
glucose levels were significantly higher in deficient group (156.76 mg/dl) as
compared to insufficient (147.91mg/dl) and sufficient group (138.28mg/dl). The
above observations suggest a highly significant correlation between the two (p
<0.0001). There was established a highly significant inverse correlation
between vitamin D3 and HbA1c and FPG levels. Conclusion- Vitamin D3 is a
potential risk factor for diabetes mellitus and has a role to play in its
pathogenesis. Not only a patient should be screened for serum vitamin D3 levels
as a possible risk factor but also as a potential beneficial role of serum
vitamin D3 supplementation in improving glycemic status in patients with
diabetes mellitus. - See more
EFFECT OF IRON AND VITAMIN C FORTIFIED CANDIES ON THE IRON STATUS OF EARLY TEENAGER
Iron deficiency anemia is the most nutrition problem in teenager period.
One possible strategy to prevent iron deficiency anemia in this group is the
fortification of favorite food as candy. So, this study was designed to know
the effect of iron and vitamin C fortified candies on the iron status of
teenager aged 10-16 y. The female teenager were randomly assigned to 3
treatment groups: A fortified group with iron (n = 20), fortified group with
vitamin C (n = 20 ) and a control group (n = 20). Candy was given to the
teenager every day for 12 wk, 5g (1 piece). The candy given to the fortified
group contained 1 mg elemental Fe ( Ferric hydroxide) /g candy and 1 mg vitamin
C (Ascorbic acid) / g candy . The results showed that the hemoglobin
concentration of the fortified groups increased to 10.6 g/L and 11.2g/L in
group 3 and from 10.6 to 12.8 in group 2 whereas that of the control group was
10.6 g/L. Anemia decreased from 50.9 % at the control group to 8.8% in group 2
and 13.3 in group 3 after 12 wk (P ≤0.05) and, the serum ferritin concentration
was lower in the control group than the fortified groups with iron and vitamin
C (P ≤0.05). From these results, it could be recommended that Iron and vitamin
C fortified candies were effective for improving the iron status of teenager
aged 10-16y and might be a good way to decrease iron deficiency in teenager of
low-to-middle income groups.
Wednesday, 20 April 2016
ASSOCIATION BETWEEN VITAMIN D RECEPTOR GENE POLYMORPHISMS AND OSTEOPOROSIS IN POST MENOPAUSAL WOMEN ATTENDING ZAGAZIG UNIVERSITY HOSPITALS
Aim:-To assess the
association between the vitamin D receptor gene polymorphisms and osteoporosis
in Egyptian postmenopausal women, to determine the genotypes most frequently
associated with decreased bone mineral density and vertebral fracture. In addition,
to assess the modulatory role of high daily calcium intake on the genetic
predisposition of osteoporosis. Patients and methods:- A total number of 92
Egyptian postmenopausal women with and without osteoporosis were diagnosed by
bone mineral density measurement were subjected to identification of VDR genes
(FOKI and BSMI) polymorphism by PCR technique followed by RFLP analysis.
Results:- The frequencies of BB, Bb and bb genotypes (BSMI polymorphism) in
osteoporotic female were 58.7%, 32.6% and 8.7%, respectively. While, in
controls their frequency was 8.7%, 17.4 % and 73.9%, respectively. The BB
genotype was higher in patients than in controls (P = 0.000) while the bb
genotype was significantly higher in controls than in patients. Regarding the
FOKI polymorphism the frequencies of FF, Ff and ff genotypes among patients
were 21.7%, 45.7% and 32.6%, respectively while their frequency in controls
were 13%, 17.4% and 69.6%, respectively. We find out that the main predictors
of osteoporosis are genotypes BB, Bb, ff in and number of pregnancy
Conclusions:- Postmenopausal females carrying B+ve or f+ve genotype were more
risky to develop osteoporosis. -
Tuesday, 19 April 2016
Writing Scientific Manuscript
Mansucript writing is an art and every researcher should learn this art.
Every sentence of your paper should be attractive and should invite the
readers to read the next one. While writing your paper, express your
facts in the way that it should create puzzle in the readers and they
should should become curious to finish up to the conclusion.
Courtesy www.journalijar.com
Courtesy www.journalijar.com
Monday, 18 April 2016
EFFECT OF IRON AND VITAMIN C FORTIFIED CANDIES ON THE IRON STATUS OF EARLY TEENAGER.
EFFECT OF IRON AND VITAMIN C FORTIFIED CANDIES ON THE IRON STATUS OF EARLY TEENAGER. more
EFFECT
OF IRON AND VITAMIN C FORTIFIED CANDIES ON THE IRON STATUS OF EARLY
TEENAGER. - See more at:
http://www.journalijar.com/article/7371/effect-of-iron-and-vitamin-c-fortified-candies-on-the-iron-status-of-early-teenager./#sthash.QyfFOW0W.dpuf
Fast Tracking Process of IJAR
We Invite Case Reports, Research papers, Review articles and Correspondence for our Coming issue April 2016 in International Journal of Advanced Research (IJAR). Kindly visit our Link www.journalijar.com for details.
BIODIVERSITY, DISTRIBUTION AND MORPHOLOGICAL CHARACTERIZATION OF MUSHROOMS IN THE SOUTH WESTERN REGION OF BANGLADESH
Department
of Plant Pathology, Faculty of Agriculture, Sher-e-Bangla Agricultural
University, Sher-e-Bangla Nagar, Dhaka-1207, Bangladesh.
The
south western region of Bangladesh is known as mangrove forest region,
positioning at 22?55\'N latitude and 89?15\'E longitudes having a wide range of
ecosystem. The present survey was conducted to record the biodiversity,
distribution and morphological characterization of mushrooms of south western
region of Bangladesh. The survey was conducted from June to October, 2014 in 5
districts namely Kushtia, Chuadanga, Jessore, Satkhira and Khulna. A total of
16 mushroom species belong to 10 genera, under 8 families were recorded during
the survey. Lepiota cristata was found abundantly in the survey areas among the
other collected species and it exhibited the maximum frequency of occurrence (25%),
whereas the maximum density (13.51%) was recorded for Hypholoma fasciculeare
and Coprinellus micaceus, followed by Lepiota cristata, Coprinus comatus and
Mycena californiensis (10.81%). Furthermore, the density of Gymnopilus
purpuratus, Coprinus sterquilinus, Marasmius oreades, Hypholoma capnoides and
Coprinellus plagioporus were recorded as 8.10%. Moreover, Lepiota cristata was
distributed in Daulatpur of Kushtia and Koira of Khulna districts in the south
western region of Bangladesh. This is the first report of macro fungi
biodiversity and their distribution in the south western region of Bangladesh. More
International Journal of Advanced Research (IJAR)
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Sunday, 17 April 2016
ASSOCIATION
BETWEEN VITAMIN D RECEPTOR GENE POLYMORPHISMS AND OSTEOPOROSIS IN
POST MENOPAUSAL WOMEN ATTENDING ZAGAZIG UNIVERSITY HOSPITALS - See more
at:
http://www.journalijar.com/article/7255/association-between---vitamin---d-receptor-gene-polymorphisms-and-osteoporosis-in-post-menopausal-women-attending-zagazig-university-hospitals/#sthash.n24vqDCz.dpufASSOCIATION BETWEEN VITAMIN D RECEPTOR GENE POLYMORPHISMS AND OSTEOPOROSIS IN POST MENOPAUSAL WOMEN ATTENDING ZAGAZIG UNIVERSITY HOSPITALS - See more at: http://www.journalijar.com/article/7255/association-between---vitamin---d-receptor-gene-polymorphisms-and-osteoporosis-in-post-menopausal-women-attending-zagazig-university-hospitals/#sthash.n24vqDCz.dpuf
Friday, 15 April 2016
CHRONIC IMMUNE THROMBOCYTOPENIA AND HELICOBACTER PYLORI INFECTION IN SUDANESE PATIENTS
Background/Aim: Immune thrombocytopenia (ITP) is an autoimmune disease
mediated by anti-platelet auto-antibodies. There is growing evidence
that the eradication of H. pylori effectively increases platelet count
in a considerable proportion of H.pylori- infected ITP patients. The
study aimed to determine sero-prevalence of H. pylori in chronic ITP
patients and to compare the ITP characteristics in H.pylori infected
and non-infected ITP patients.
Patients/Method: the study was done on 60 already diagnosed ITP patients
of at least 6|12 duration. On all patients were done Complete blood
count (CBC), blood cells morphology (thin film), IgG for H.pylori
antibodies and anti-platelet antibodies by ELISA. Anti-lewis antibodies
were done by a serological method. All patients were screened for
hepatitis B, C and HIV by ICT. The initial platelets count at diagnosis
was obtained from the patients note and bone marrow examination
performed by consultant hematologist. Their ages ranged between 2-74
years, there were 21 males and 39 females. 57 patients already were
underwent corticosteroids treatment.
Results: Anti H.pylori IgG, Anti-platelets, and anti-Lewis abs were
detected in 63%, 58%, and 28%, respectively. There was a significant
difference between platelets count at time of diagnosis and time of
enrolling, P: < .00001. Moreover, a significant difference was found
in platelets count at time of enrolling between H. pylori sero-positive
and sero-negative ITP patients, P: 0.00006. In ITP treated patients
(57/60) there was a significant rise in platelets count after compared
to the initial count, P: 0.00001. In comparison of ITP characteristic
between H.pylori sero-positive and sero-negative ITP patient; there was a
significant difference in regard to anti-platelets antibodies status,
P: 0.0001, platelets count at time of enrolling P: 0.00006, and
corticosteroid response, P: 0.01.
Conclusion: Anti -H.pylori and anti-platelets antibodies were frequent
in ITP patients. Reduction in the platelet count was observed in
H.pylori sero-positive ITP patients than sero-negative ones. In the
majority of H.pylori sero-positive ITP patients; thrombocytopenia still
persists even in those patients who underwent corticosteroids treatment.
- See more at:
http://www.journalijar.com/article/7906/chronic-immune-thrombocytopenia-and-helicobacter-pylori-infection-in-sudanese-patients./#sthash.niBVtXDQ.dpuf
Background/Aim: Immune thrombocytopenia (ITP) is an autoimmune disease
mediated by anti-platelet auto-antibodies. There is growing evidence
that the eradication of H. pylori effectively increases platelet count
in a considerable proportion of H.pylori- infected ITP patients. The
study aimed to determine sero-prevalence of H. pylori in chronic ITP
patients and to compare the ITP characteristics in H.pylori infected
and non-infected ITP patients.
Patients/Method: the study was done on 60 already diagnosed ITP patients
of at least 6|12 duration. On all patients were done Complete blood
count (CBC), blood cells morphology (thin film), IgG for H.pylori
antibodies and anti-platelet antibodies by ELISA. Anti-lewis antibodies
were done by a serological method. All patients were screened for
hepatitis B, C and HIV by ICT. The initial platelets count at diagnosis
was obtained from the patients note and bone marrow examination
performed by consultant hematologist. Their ages ranged between 2-74
years, there were 21 males and 39 females. 57 patients already were
underwent corticosteroids treatment.
Results: Anti H.pylori IgG, Anti-platelets, and anti-Lewis abs were
detected in 63%, 58%, and 28%, respectively. There was a significant
difference between platelets count at time of diagnosis and time of
enrolling, P: < .00001. Moreover, a significant difference was found
in platelets count at time of enrolling between H. pylori sero-positive
and sero-negative ITP patients, P: 0.00006. In ITP treated patients
(57/60) there was a significant rise in platelets count after compared
to the initial count, P: 0.00001. In comparison of ITP characteristic
between H.pylori sero-positive and sero-negative ITP patient; there was a
significant difference in regard to anti-platelets antibodies status,
P: 0.0001, platelets count at time of enrolling P: 0.00006, and
corticosteroid response, P: 0.01.
Conclusion: Anti -H.pylori and anti-platelets antibodies were frequent
in ITP patients. Reduction in the platelet count was observed in
H.pylori sero-positive ITP patients than sero-negative ones. In the
majority of H.pylori sero-positive ITP patients; thrombocytopenia still
persists even in those patients who underwent corticosteroids treatment.
- See more at:
http://www.journalijar.com/article/7906/chronic-immune-thrombocytopenia-and-helicobacter-pylori-infection-in-sudanese-patients./#sthash.niBVtXDQ.dpuf
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