Aim:-To assess the
association between the vitamin D receptor gene polymorphisms and osteoporosis
in Egyptian postmenopausal women, to determine the genotypes most frequently
associated with decreased bone mineral density and vertebral fracture. In addition,
to assess the modulatory role of high daily calcium intake on the genetic
predisposition of osteoporosis. Patients and methods:- A total number of 92
Egyptian postmenopausal women with and without osteoporosis were diagnosed by
bone mineral density measurement were subjected to identification of VDR genes
(FOKI and BSMI) polymorphism by PCR technique followed by RFLP analysis.
Results:- The frequencies of BB, Bb and bb genotypes (BSMI polymorphism) in
osteoporotic female were 58.7%, 32.6% and 8.7%, respectively. While, in
controls their frequency was 8.7%, 17.4 % and 73.9%, respectively. The BB
genotype was higher in patients than in controls (P = 0.000) while the bb
genotype was significantly higher in controls than in patients. Regarding the
FOKI polymorphism the frequencies of FF, Ff and ff genotypes among patients
were 21.7%, 45.7% and 32.6%, respectively while their frequency in controls
were 13%, 17.4% and 69.6%, respectively. We find out that the main predictors
of osteoporosis are genotypes BB, Bb, ff in and number of pregnancy
Conclusions:- Postmenopausal females carrying B+ve or f+ve genotype were more
risky to develop osteoporosis. -
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