Background- Vitamin D3
is known for its calcium absorption and bone metabolism; but now been
recognized as an accessible predictor, risk factor and biomarker of type 2
diabetes mellitus (T2DM). Aim- The aim of the study is to determine serum
vitamin D3 levels in T2DM patients and ascertain its correlation with HbA1c.
Setting and design- This is a cross-sectional study through screening of
patients with T2DM attending the OPD/ indoor of SGRDIMSR, Amritsar. Material
and method- With prior informed consent, 100 diabetic patients were examined
for complications of diabetes and investigated for HbA1c, serum calcium and
vitamin D3 levels in addition to routine investigations. Vitamin D3 levels were
determined and relation with HbA1c levels was established. Results- Among the
100 T2DMpatients, 46% had deficiency, 22% had insufficiency and 32% had
sufficiency of vitamin D3. The mean HbA1c value was 7.74 ? 1.63% in vitamin D
sufficiency, 9.83 ? 2.02% in insufficiency, and 9.91 ? 2.5% in deficiency
making the correlation highly significant (p <0.0001). The fasting plasma
glucose levels were significantly higher in deficient group (156.76 mg/dl) as
compared to insufficient (147.91mg/dl) and sufficient group (138.28mg/dl). The
above observations suggest a highly significant correlation between the two (p
<0.0001). There was established a highly significant inverse correlation
between vitamin D3 and HbA1c and FPG levels. Conclusion- Vitamin D3 is a
potential risk factor for diabetes mellitus and has a role to play in its
pathogenesis. Not only a patient should be screened for serum vitamin D3 levels
as a possible risk factor but also as a potential beneficial role of serum
vitamin D3 supplementation in improving glycemic status in patients with
diabetes mellitus. - See more
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