ASSOCIATION BETWEEN VITAMIN D RECEPTOR GENE POLYMORPHISMS AND OSTEOPOROSIS IN POST MENOPAUSAL WOMEN ATTENDING ZAGAZIG UNIVERSITY HOSPITALS

Abstract: Aim:-To assess the association between the vitamin D receptor gene polymorphisms and osteoporosis in Egyptian postmenopausal women, to determine the genotypes most frequently associated with decreased bone mineral density and vertebral fracture. In addition, to assess the modulatory role of high daily calcium intake on the genetic predisposition of osteoporosis. Patients and methods:- A total number of 92 Egyptian postmenopausal women with and without osteoporosis were diagnosed by bone mineral density measurement were subjected to identification of VDR genes (FOKI and BSMI) polymorphism by PCR technique followed by RFLP analysis. Results:- The frequencies of BB, Bb and bb genotypes (BSMI polymorphism) in osteoporotic female were 58.7%, 32.6% and 8.7%, respectively. While, in controls their frequency was 8.7%, 17.4 % and 73.9%, respectively. The BB genotype was higher in patients than in controls (P = 0.000) while the bb genotype was significantly higher in controls than in patients. Regarding the FOKI polymorphism the frequencies of FF, Ff and ff genotypes among patients were 21.7%, 45.7% and 32.6%, respectively while their frequency in controls were 13%, 17.4% and 69.6%, respectively. We find out that the main predictors of osteoporosis are genotypes BB, Bb, ff in and number of pregnancy Conclusions:- Postmenopausal females carrying B+ve or f+ve genotype were more risky to develop osteoporosis. - See more at: http://www.journalijar.com/article/7255/association-between---vitamin---d-receptor-gene-polymorphisms-and-osteoporosis-in-post-menopausal-women-attending-zagazig-university-hospitals/#sthash.mJxjnd1t.dpuf

http://www.journalijar.com/article/7255/association-between---vitamin---d-receptor-gene-polymorphisms-and-osteoporosis-in-post-menopausal-women-attending-zagazig-university-hospitals/