Obesity, characterized by an increase in body
weight that results in excessive fat accumulation, represents a social problem
worldwide and has been recognized as a major factor for the pathogenesis of
several diseases. Obesity is one of the most important risk factor for CVD. The
goal of the present study was to evaluate the biochemical and molecular
instabilities in obesity and its risk for cardiovascular disease. Thirty one
obese subjects were selected as study subjects and twenty five healthy subjects
without any chronic illness were selected as control for the present study. The
role of oxidative stress measured by the level of oxidative stress marker,
Malondialdehyde (MDA) and the DNA damages were quantified by Cytokinesis-Block
Micronuclei (CBMN) assay. Detailed demographic, clinical and lifestyle
characteristics were compared with subjects. The MDA value and the micronuclei
frequency was significantly elevated in study subjects as compared with that of
control subjects. Obese individuals experience substantially elevated morbidity
and mortality from all forms of CVD. - See more at:
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