Saturday 28 May 2016

CHANGES OF SERUM CARDIAC MARKERS AFTER ACUTE ATTACK OF MYOCARDIAL INFARCTION

CHANGES OF S. CARDIAC MARKERS AFTER ACUTE ATTACK OF MI BACKGROUND: Blood testing for biomarkers of myocardial injury plays an important role for the evaluation, diagnosis, and triage of patients with chest pain. The criteria for the diagnosis of myocardial infarction have been redefined recently, as reported in a document of the European Society of Cardiology (ESC) and the American College of Cardiology (ACC), and require at least 2 of the 3 following characteristics: (1) typical symptoms; (2) characteristic rise-and-fall pattern of a cardiac markers or (3) a typical electrocardiogram (ECG) pattern involving the development of Q waves. Currently serum troponins, can now detect extremely small amounts of myonecrosis (<1.0 g), which, in the setting of an ACS, may be associated with increased risk of complications. MATERIALS AND METHODS: Patients are selected from those attending department of medicine, G.G. Hospital, M.P. Shah Medical College, Jamnagar. Blood samples of patients were taken to measure the serum LDH, Troponin I, CRP, CK-MB levels by ELISA (enzyme linked immunosorbent assay) and their levels are compared with clinical condition, ECG changes and prognosis of the patients. RESULT: Out of 100 patients studied 70 patients were in age group 40-70yrs, 74 patients were having history of hyper tension and 55 patients were having complaint of chest pain were diagnosed as having acute MI. CONCLUSION: Troponins are ideal markers which enable early detection of patients with acute coronary syndrome whereas inflammation markers are helpful in diagnosis and assessing the severity of inflammation - See more at: 

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