Methods: 30 hypertensive diabetic subjects of type II (18 males and 12
females) with an average age of (55 ?15 years) and average weight (61 ?16.5 kg)
were participated in this study. 17 subjects were on Captopril therapy
(50mg/daily) and 13 subjects were on Atenolol therapy (50mg/daily). 30 healthy
volunteers of comparable age (52 ? 15 years ) and an average weight (85.5?15.5
kg) was used as control sample. Two venous blood samples were collected from
each subject, first blood sample was taken before drug therapy and the second blood
sample was taken three weeks after drug therapy. Objectives: In vivo study was
carried out to monitor the effect of antihypertensive drugs (Captopril and
Atenolol) on the metabolites and enzymes that are requested for professional
diagnosis in diabetic patients. Results: Captopril therapy significantly
elevated Total protein (TP), Creatinine, Total cholesterol, Triglyceride, and
Creatine kinase (CK) whereas Total bilirubin (T.bil.) was significantly
reduced. Total cholesterol (T.Chol.), Triglyceride (TG) and Alanine
transaminase (ALT) were found significantly increased in patients with Atenolol
therapy. Conclusion: Among the antihypertensive drugs, Atenolol has less effect
on all biochemical laboratory parameters and therefore it is more favorable
than Captopril. - See more at:
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