Monday 30 May 2016

Association of TGF-β1 Polymorphism with Type 2 Diabetes Mellitus and Diabetic Nephropathy in Saudi Patients.

Diabetic nephropathy is the common process that is leading to ESRD. Several studies showed that TGF-β is a major anti-inflammatory cytokine involved in extracellular matrix deposition and thickening of basement membrane of glomeruli. This study is aimed to evaluating the association of TGF-β1 gene polymorphisms (869T/C) and (509C/T) with complicated and uncomplicated type 2 diabetes mellitus. Methods: 250 Saudi male classified into; 100 healthy males as control, 80 uncomplicated type 2 diabetes mellitus male patients and 70 type 2 diabetes mellitus male patients with nephropathy. Blood and urine samples were collected from all groups for measurement of plasma glucose, urea, cholesterol, triglyceride, HDL-C, urea, creatinine and TGF-β1. In addition a genotyping of TGF-β1 was done. Results: our results showed a statistical difference in TGF-β1 levels in all groups, also a positive correlation between hyperglycemia and HbA1c with TGF-β1 level was detected. According genotype, only 869T/C genotypes are involved in susceptibility to T2DM and diabetic nephropathy. Both TC and CC genotype are higher in T2DM patients compared with control (P<0.05), while only CC is higher in diabetic nephropathic patients compared with uncomplicated T2DM (P<0.05). Conclusion: an increase TGF-β level may be involved in processes of T2DM development and its nephropathic complication. In addition, the TC and CC genotypes of TGF-β1 869T/C are more susceptible to T2DM, while only CC genotype to diabetic nephropathy.see more

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