Background: Astrocytoma is the commonest central nervous system tumor
worldwide. Searching in molecular pathogenic processes of its progression is
necessary to identify novel therapeutic targets to improve the clinical outcome
of patients. Epithelial-mesenchymal transition (EMT) is the process by which
cells lose their adhesive properties with surrounding cells and then they
transformed into mesenchymal-like and motile phenotypes. Snail-1 is a zinc
finger transcription factor that plays an essential role in EMT. Beta-catenin
is a protein that binds to the cytoplasmic tail of E-cadherin. In the presence
of mutations of Wnt-signal; it promotes transcription of several target genes
involved in cell proliferation. Aim of the work: To asses Snail-1 and Beta-catenin
immune-expressions in astrocytoma of different grades in a trial to detect
their prognostic values in that tumor. Methods: Immunohistochemical staining of
Snail-1 and Beta-catenin was evaluated in 60 paraffin blocks of astrocytoma
grades II, III and IV. The relationships between their expressions and
clinicopathological parameters were analyzed. Results: The expressions of
snail-1 and beta-catenin were signifi?cantly associated with astrocytoma grade
(p=0.001 and 0.007 respectively) type of surgery, performance status, response
to treatment (p <0.001) and progression of the tumor (p=0.048, 0.012
respectively). High Snail-1 and high Beta-catenin immune-expressions were
inversely related to The 1, 2 and 3-year OS (P <0.001). Conclusion: Snail-1
and beta-catenin expressions were frequently increased in astrocytoma and
significantly associated with poor prognosis. - See more at:
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