Objective:- To examine the effect of intravaginal dehydroepiandrosterone
on vagina and endometrium specially on symptoms and signs of vaginal atrophy
and sexual dysfunction in postmenopausal women. Material and Method:- Study was
conducted on 128 postmenopausal women between 40-75 year of age, presented with
symptoms of vaginal atrophy and sexual dysfunction. Vaginal pH was determined,
vaginal smear was examined for maturation index and maturation value, and endometrial
biopsy was taken before and after intravaginal application of 0.5%DHEA ovules
daily for 12 weeks. Results:- With DHEA, symptoms of sexual dysfunctions
decreased significantly in 67% women (p<0.05), vaginal symptoms improved in
60% women (p<0.05).Vaginal pH was decreased by 1.1?0.06 unit (p<0.0001).
Percentage of case with pH≤5 was increased to 79% from 34%, of parabasal cells
decreased from 59.84?2.0 to 30.59?0.98 (p<0.0001) and of superficial cells
increased by 8.66?0.18 (p<0.0001), maturation value increased by 20?0.63
(p<0.0001). Endometrial biopsy seen at the start of treatment remained
unaffected by DHEA. Conclusion:- DHEA has many benefits of estrogen, with no
side effects, and helps women with vaginal atrophy to stimulate the cellular
growth of the vaginal wall and increase vaginal secretion, thus restoring the
vagina to its youthful condition. - See more at:
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