Gram-negative bacilli producing extended-spectrum beta-lactamase (ESBL)
comprise an important interest in human medicine today. It was verified that
pathogenic bacteria may efficiently inactivate the newer third-generation
Cephalosporins (such as cefotaxime, ceftazidime, and ceftriaxone). This study
was designed to determine the prevalence of extended-spectrum β-lactamases
(ESBLs) among gram-negative isolates obtained from river water specimens with
double disc diffusion synergy test. Ten fresh river water specimens were
collected from upstream, midstream and downstream of Tigers River in Baghdad
City. Additional thirty five municipal drinking water specimens were collected
from various public water supplies in Baghdad City. Microorganisms isolated
from all specimens were identified at species level according to standard
microbiology methods. Isolates resistant to cefotaxime were tested for ESBL
production by double disc synergy test. Fresh water specimens detected (7%)
ESBL-positive environmental isolates, whereas municipal drinking water
specimens recorded (20%) ESBL-positive environmental isolates. E. coli, Prot.
Mirabilis, and Ent. cloacae were the most prevalent ESBL-positive isolates in
environmental water specimens. Our study therefore, does not only declare the
presence of ESBL producing Enterobacteriaceae but also confirm that they are
multi-drug resistant. More research work is required using molecular techniques
to specifically find out the genes responsible for this grave resistance. - Seemore at:
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