Hematological findings in favism among children admitted to Karbalateaching hospitalof children ( in Iraq ).

Back ground:-Glucose-6-phosphate dehydrogenase (G-6-PD) deficiency is a hereditary condition in which red blood cells break down when the body is exposed to certain drugs, stress of infection or oxidant effect of certain substances like that which find in fava bean . Aim of study:-To identify common laboratory findings in children complain from hemolytic crisis due to fava bean ingestion admitted to hospital. Methods:-This cross-sectional study was conducted in Karbala teaching hospital of children in holy Karbala city in Iraq during the period from February 2014 through July 2014. We toke 100 child complained from acute hemolytic anaemia from them we selected forty patients their age range from 8 month to 12 years Result:-Cases were 40, 31 were males and nine were females, there age range from 8 months to 10 years. Most of them were from urban areas and mostly were recorded with in April and March, Most of them were O + blood group and the lowest frequencies was AB + blood group, Allcomplain from reduced in RBCs mass and reduced hemoglobin level also we found in most of cases there is significant leukocytosis with predominant neutrophil. Platelets count was within normal range in both male and female while reticulocytes count were significantly increased. In blood film there were many blister, horn cells and nucleated RBCs. G6PD enzyme assaywas deficient in 36 out of 40. Conclusion:-Favism affect male more than female especially pediatric age and more common during March and April. All cases complain from significant changes in complete blood picture and reticulocytosis.Morphological changes in RBCs as blister, horn cells and Heinz body cells. Enzyme qualitative evaluation was deficient in 90% of the cases -See more at: