The present study was designed to determine the possible protective
effects of date palm extract against Cerastes cerastes venom induced oxidative
stress and biochemical changes in liver of albino rats. A patch of 104 male
Wister albino rats averaged weights (130?10g) at the beginning of the
experiment were divided into 6 main groups according to the treatment and
requirements of the experiment. Control rats group, DPE group treated orally
with DPE at dose 1.2 mg/kg body weight, venoms groups: Rats injected with a
single dose of Cerastes cerastes for one day, this group divided into three
subgroups injected by a single dose of 1/4 LD50, 1/2 LD50 and LD50 for one day
also for two weeks groups, venoms treated with DPE groups treated orally with
DPE for two weeks before /and after injecting of a single dose of venom at dose
1/4 LD50, 1/2 LD50 and LD50 for one day. Each group contains 6 rats except
venom groups of LD50 were 8 rats and six rats were sacrificed after the 1st
day, 2nd and 4th week from each group of treatment. The results showed a
significant raise of some hepatic parameters (ALAT, ASAT, ALP, TG, CHO and
LDL-C), while a significant reduction in some other parameters (Total protein,
albumin and HDL-C), on the 1st day and 2nd weeks in rats injected
intraperitoneal with Cerastes cerastes venom as compared to the control groups.
The administration of the DPE ameliorated the side effects of the poisonous
changes of Cerastes cerastes venom. In conclusion, according to the results
obtained revealed that the administration of DPE had hepatoprotective effects
against envenomation with Cerastes cerastes venom in male Wister albino rats by
inhibiting oxidative stress through ROS scavenger and improvement of the
biochemical markers. - See more at:
No comments:
Post a Comment