Background:- 25-hydroxyvitamin D [25(OH)D] concentration is inversely
associated with cardiovascular disorders including coronary arterial disease
and hypertension. Vascular remodeling may play a role in this association,
however, few data relating vitamin Dlevel to specific remodeling biomarkers
among ESRD patients is available. We investigated whether 25(OH)D levelis
related to markers of vascular remodeling in ESRD patients. Subjects &
Methods:- It included a total number of 65 subjects. They were divided into
three groups: Group 1 (29 subjects with severe vitamin D deficiency on regular
hemodialysis), Group 2 (14 subjects with moderate vitamin D deficiency on
regular hemodialysis) and Group 3 (22 subjects with normal vitamin D level on
regular hemodialysis). All patients included in this study were subjected to
the following: Full clinical assessment, Complete blood picture, alanine
aminotransferase, aspartate aminotransferase, serum albumin, creatinine, blood
urea, fasting plasma glucose, serum calcium, serum phosphorus, serum
parathyroid hormone, lipid profile, 25 hydroxyvitamin D and MMP9 levels.
Results:- Among 65 patients, mean?standard deviation 25(OH)D concentration was
25.27?18.08, and was low(<20ng/ml) in 44.6% of patients. 25(OH) D
concentration was inversely correlated withMMP-9 concentration (r = -0.607, p
<0.001). In multivariate analysis, MMP-9 concentration remained
negativelyassociated with 25(OH) D concentration (P = 0.001). Conclusion:- We
detected thatplasma MMP-9 and circulating 25(OH) D concentrations are
significantly and inversely associatedamong ESRD patients on hemodialysis. This
finding may suggest a potential mechanism by which low circulating 25(OH)
Dfunctions as a cardiovascular risk factor. - See more at:
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