Bisphenol-A (BPA) is a worldwide used endocrine disruptor that is
incorporated in many plastic industries. The exposure of humans to such
substances starts early during the fetal life, postnatal life and extends
throughout the life of the individual. Many agencies raised warnings against
the excessive use of such substances. The aim of the present study is to
evaluate the extent to which BPA can affect the liver, kidney and ovaries by
measuring the oxidative stress induced by two different doses of BPA in these
organs of pregnant rats; these rats were treated to different oral doses of BPA
(25 mg/kg, 50mg/kg and 50mg/kg/b.wt). The oxidative stress arising from BPA was
evaluated in liver, kidney and ovary tissues. In addition, serum urea and
createnine levels as markers of kidney function together with the activities of
MDA, catalase, GSH, GST as markers of liver function were measured. The results
of the present study showed significant changes in the antioxidant mechanisms
in the liver, kidney and morphological changes in ovaries with the lower (25
mg/kg, 50mg/kg for 9-days) and higher doses of BPA (500 mg/kg for 9-days). It
could be concluded that BPA-induced toxicity is mediated by oxidative stress
which was prominent in liver, kidney and ovaries after the exposure to both the
higher and lower doses. - See more at:
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