The objective of this research was to develop and validate an
alternative accurate method for quantitative determination of probenecid in
tablet dosage form. Probenecid is a highly lipid soluble 4-[(di-propyl amino)
sulfonyl] benzoic acid having consistent uricosuric action for treatment of
hyperuricaemia and gout. Probenecid was estimated using dilute sodium hydroxide
at 243nm and the percentage recovery was found to be 100.2 ± 0.34. The method
was tested and validated for various parameters according to the ICH guidelines.
In proposed method relative standard deviation value less than 2% for the
routine analysis of drug in tablet form. The limit of detection and limit of
quantitation were 0.5µg/ml and 1.5µg/ml respectively. Results shows that the
developed method is simple, reproducible and successfully for the estimation of
probenecid in tablet dosage form without the interference of common excipients.
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