The synthesis of four metal complexes of hydrochlorothiazide Schiff base
is reported. The compounds were obtained by the condensation of
hydrochlorothiazide and salicylaldehyde, followed by the synthesis of their Cd(II),
Ni(II), Zn(II) and Co(II) metal complexes. Structural characterization was done
using 1H and 13C NMR, MASS, IR, UV-Vis spectroscopy and elemental analysis.
Prepared compounds were screened for their antimicrobial activity. Obtained
results were compared with those of parent drug hydrochlorothiazide. The
increased antimicrobial potency of all compounds were recorded; excellent
activity was reported for Co(II) and Cd(II) complexes. - See more at: .
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