ANTIOXIDATIVE EFFECT OF PUNICA GRANATUM (POMEGRANATE) ON BIOCHEMICAL PARAMETERS IN PATIENTS WITH DIABETES MELLITUS (TYPE 2) AND MYOCARDIAL INFARCTION: A DOUBLE BLIND PLACEBO CONTROLLED TRIAL. - .

Results were analyzed, Z test and chi square indicates that significant difference has been observed after active medication. Coefficient of Variations (C.V.) shows that when mean of active and placebo were compare to each other; patients who were under “add-on” therapy of PEWF for one month, showed highly significant. This indicates the prognostic effect of PEWF in patients with T2D with MI. Total 40 patients of either gender with T2D and MI were included in this study. Demographic information, Clinical and Biochemical investigation related to T2D were processed in 4 ml fasting venous blood. All participants were assigned in two groups of 20 each. One group were under “Add On” therapy of Active Drug which includes Pomegranate extract of whole fruit (PEWF) (300 mg twice daily for One Month), matching Placebo of same color, shape and size was used as comparator agent for second group. The Drug was issued to the Patients initially for 15 days after which they were recalled for clinical valuation, compliance monitoring, adverse effect monitoring if any; and drug refill for next 15 days. At the end of one month, the base line investigations were repeated. Patients were followed for next 3 months; on 4 month level of HbA1C was monitored to check the status of T2D. Hypoglycemic drugs; which are usually prescribe to cure T2D are either too expensive or have sides effects on Hematological, Liver and kidney functions. WHO recommends to use alternative medicine to cure T2D because herbal products are natural and don’t have such side effects. One of such herb is pomegranate; usually consumed as fruit. As per Ayurvedic literature, Pomegranate seeds may cure T2D and pulps contain lots of antioxidants. This prompted us to find out; whether the presence strong antioxidants in pomegranate have any prognostic effects in patients with T2D? So we prepared a Whole Fruit Extract of Pomegranate (PEWF) to investigate its effect in patients with T2D. Diabetes Mellitus Type 2(T2D) is one of the leading disease in worldwide. Approximately 177 million peoples in worldwide are effected with T2D. T2D is a heterogeneous metabolic disorder, which is characterized by hyperglycemia and cardiovascular complications. Pathogenesis of T2D is absolute or relative deficiency of insulin and insulin resistance. Patients with T2D are highly prone oxidative stress because hyperglycemia depletes natural antioxidants. - See more at: .