Thursday 16 June 2016

AMELIORATION OF CURCUMIN AGAINST CADMIUM INDUCED OXIDATIVE STRESS IN LUNG OF ALBINO MICE. .

Humans are exposed to a number of toxic elements in the environment. Cadmium, is a great environmental health problem of both humans and animals. The present study was carried out to evaluate the protective role of curcumin on lung against cadmium chloride induced oxidative stress in albino mice. Albino mice were divided into 4 groups. Group 1 mice were kept as control. Group 2 mice were administered an oral dose of 1mg/kg body weight of Cd on alternate days for 15 days. Group 3 mice were given an oral dose of 1mg/kg body weight of Cd on alternate days and 100mg/kg body weight of curcumin daily for 15 days. Group 4 mice were given an oral dose of 100 mg/kg body weight of curcumin daily for 15 days and will be kept as positive control. Autopsies were done on 15 days post treatment. A significant decrease in body weight and organ weight were observed. Biochemical analysis showed decline in antioxidant activity of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidise (GPx) and increase in lipid peroxidation. However, the treatment with curcumin ameliorated Cd-induced malondialdehyde (MDA) and oxidative stress in lung tissue as it provoked the antioxidant defense system more significantly. While, co-treatment of Cd with curcumin ameliorated the antioxidant level. The results of the present research work showed the protective action of curcumin on the cadmium induced oxidative stress in the lung of mice. - See more at: .

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