Objectives: Although acute exhaustive exercise increases oxidative
stress, regular exercise programs strengthen oxidant protection. The aim of
this study was to investigate the effects of high altitude training on
malondialdehyde (MDA) as index of lipid peroxidation. We also aimed to
investigate the incidence of gene polymorphism of the manganese
superoxidedismutase (Mn-SOD), glutathione peroxidase-1 (GSH-Px1) and catalase
(CAT) enzymes. Materials and Methods: Thirty male subjects between the ages of
20 to 25 trained at a high altitude camp at 2750 meters for 10 days. The
subjects were divided into 3 groups: athletic (n=10), sedentary (n=10), and
sedentary control (n=10). While the athletic and sedentary groups performed
aerobic exercise at high altitude, the sedentary control group did not partake
in any physical exercise. Blood samples were obtained pre-exercise,
post-exercise, before ascent, on the 1st, 5th and 10th days at high altitude,
and after descent. Results: There were significant statistical difference in
CAT and GSH-Px1 activity prior to ascent, at high altitude and on the1st, 5th,
and 10th days at high altitude and after descent (p<0.05). However, there
were no statistically significant differences between groups with respect to
plasma MDA and SOD levels(p>0.05). There was a statistically significant
difference in terms of CAT genotype between groups (p<0.05). However, there
were no statistically significant differences for Mn-SOD and GSH-Px1 genotype
among the groups of before ascent, at high altitude, on the 1st, 5th and 10th
days at high altitude and after descent (p>0.05). For both genes, we did
observe a statistically significant difference for CAT allele (p<0.01).
However, there were no differences between the groups in terms of allele
frequency. Conclusion: We concluded that high altitudemight play a role in the
gene activity of oxidative stress and antioxidant enzymes. - See more at.
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