Levels of Tumor Necrosis Factor alpha (TNF,cachexin or cachectin and
formerly known as tumor necrosis factor alpha) a cytokine involved in systemic
inflammation was studied in 30 newly diagnosed AML patients before and after 4
week combination chemotherapy of cytarabine and an anthracycline
(daunorubicin), APL patients were treated with tretinoin plus concurrent
anthracycline chemotherapy followed by maintenance therapy with either tretinoin
or chemotherapy. 30 age and sex matched healthy controls were taken. The
present study was conducted in the department of Biochemistry in collaboration
with Department of Medicine (Clinical Hematology Unit); Pt. B. D. Sharma
PGIMS,Rohtak. TNF levels at diagnosis were significantly higher in patients not
achieving remission than levels in patients achieving remission
(p=0.015).Levels of TNF decreased significantly after therapy only in remission
group. - See more at: .
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