Aim: The present study evaluates the clinical and immunological efficacy
of 0.3% of Triclosan gel as a topical drug application system for the treatment
of chronic periodontitis patients in terms of plaque index, gingival index,
probing depth, clinical attachment levels (clinical parameters) & level of
cytokine IL-1 ?using ELISA. Materials & Methods: A total of 30 patients
suffering with chronic periodontitis (20-50 years) were selected & randomly
divided equally into two groups to be treated with scaling and root planing
(SRP) + 0.3% Triclosan gel (test group) & SRP (Control group) alone. The
clinical parameters were assessed at baseline & 30 days, along with the
immunological parameters at baseline and 30 days post treatment. Results:
Statistically significant reduction in plaque was achieved for both the groups
while reduction in gingival index was statistically significant in test group
only. When compared to baseline mean pocket probing depth was found to be
significantly reduced in test group in comparison to control group. Clinical
attachment levels showed statistically significant reduction in both the groups
from baseline to 30 days and no significant difference were present in both the
groups. Further Test Group demonstrated a statistically significant reduction
in level of cytokine IL-1? as compared to Control group from baseline to 30
days. Conclusion: This study, thus demonstrated that 0.3% Triclosan gel can be
effectively used as a topical drug delivery system as an adjunct to scaling and
root planing for the treatment of in chronic periodontitis patients. - See moreat: .
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