Background:- ESRD is a major healthcare problem worldwide, especially in
developing countries. Nutrition disorders especial anemia and loss of weight
are very common and important risk factors for morbidity and mortality in
patients on regular hemodialysis and so We aimed to evaluate the relationship
between serum leptin,anemia and nutrition state in patients on regular
hemodialysis Subjects and methods:- A case- control study included 55 Egyptian
patients on chronic hemodialysis 34 healthy subjects as control. Each group
were stratified according to their body mass index (BMI) to four subgroup, In
all studied participants we determined BMI, body surface area (BSA) and waist
to hip ratio (WHR), blood urea, serum creatinine, sodium, potassium , calcium,
phosphorus , albumin, serum bilirubin. ALT, AST, complete blood count, Lipid
profile, HbA1c, fasting blood glucose (FBG), post prandial blood glucose were
measured.Also,we estimate serum leptin andCRP levels. Results:- there were
highly statistical significance differences between cases and control in Leptin
and CRP with marked elevated level in hemodialysis group(HD)compared to control
group.There was positive correlation between BMI and leptin in cases group with
marked elevated level in obese and over- weight compared to under -weight and
normal cases but there was no significant correlation in control group. In
hemodialysis group,there was non- significant correlation between CRP and
leptin level.Linear regression analysis showed that, serum leptin levels were
independently correlated with diastolic blood pressure and platelet in
hemodialysis group. Conclusion:- In the present study, serum leptin and CRP
levels were higher in Egyptian patients. On regular hemodialysis, there were
significant positive correlation between serum leptin levels and BMI. According
to the results of this study, serum leptin can be used as diagnostic marker of
nutrition disorders especially anemia and weigh changes in patients with ESRD
on hemodialysis - See more at:
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