Bioassay drugs and their Cu (II) ion-pairs, phenylazo compounds with Ni (II) and Cu (II) complexes on the flour beetle, Triboliumconfusum (Coleoptera : Curculionidae).

The flour beetles Triboliumconfusum were biologically affected after exposure to dose 10?g/insect of Ibuprofen, naproxen, lornoxican, Indomethacin, and phenylazo compounds. The survival adult of T. confusum was decreased by increasing chemical doses. Higher biorational effect of drugs was 73% of adult mortality after treatment with lornoxicam at dose 50?g; while the same compound had antagonistic effect when attached with Cu (II) which caused 38% of adult mortality. Contrary synergistic effect when Cu(II) ion was attached into Ibuprofen drug; where it produced 86% of adult mortality with Cu (II) and 41% without Cu(II). Also the bioactivity of phenylazo compounds, R1 (p-OCH3) and R2 (p-NO2) was increased by attachment to Ni (II) and Cu (II) ions; while it was decreased effect of compounds R3 (p-Br) and R4 (p-H) attachment to Ni (II) and Cu (II) ions. Bioactivity action of the compound R1 was 73 and 83 mortalities at dose of 50?g when attached to Ni (II) and Cu (II) ions respectively; while it was 68% without attachment to the same ions. The compound R3 was the most active one against T. confusum, where it recorded 100% of adult mortality at the dose of 30 ?g. Therefore; it is concluded that the drugs and phenylazo compounds and their copper and nickel attachment are appropriate probe as bioactive compounds on Vertebrates and Invertebrates. -see more