The aim of this study was to investigate
the effects of exogenous leptin administration on some stress indicators in
streptozotocin (STZ)-induced diabetes rats.In this study wistar albino rats
were divided into two main groups (first was 5 day, and second was 10 day),
each one subdivided into four groups (5 rat per subgroup): 1. Control, 2.
Leptin (10 μg/kg leptin, sc. daily), 3. Diabetes, (induced by single injection
of streptoztocin (65 mg/kg bw)) 4. Leptin + diabetes. At the end of the
experiments the blood collected by cardiac puncture under anesthesia. Plasma
catalase, glutathione, malondialdehyde, and IL-6 levels were measured. Our
results showed that diabetes decrease glutathione and catalase levels and
increase MDA and IL-6 levels, while leptin treatment reverse these changes.see more
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