Background:Mumps is caused by a RNA virus belonging to the myxo virus
group. One of its most notorious complications is mumps orchitis. Although it
may cause infertility in some of the affected males, the exact mechanisms of
fertility impairment are not entirely understood. Mumps viruses can attach to
the sperm surface, and, serving as haptens, lead to the production of sperm
antibodies. Aims and objectives: 1. To know if there is a relation between the
infection by mumps after puberty and the result of seminal fluid analysis. 2.
To determine the presence of anti-sperm antibodies(ASAs) in male serum and
semen. 3. To know the relation between pumps in puberty and the ASAs in semen
and serum of infertile males. Patients and methods:A cross sectional study carried
in subfertility care and IVF centre in Erbil city in Iraqi Kurdistan from
November 2013- September, 2014. 200 infertile males were included in the study.
A semen specimen was collected and analysed for semen parameters, the seminal
fluid analysis of semen was classified the seminal fluid to normal and abnormal
according to WHO guideline. Serum and semen collected from males for detection
of antisperm antibodies by using ElISA (enzyme linked munosorbent assay) used
for detection ASAs in the serum of males and also for detection ASAs in male
seminal fluid qualitatively. Result:The mean age of infertile male participated
in the study was (33.905 year ) with maximum and minimum age was (51year, 22
year ) respectively, among 200 male the frequency of males with history of
mumps after puberty was 26 which represents about 13% of infertile male whom
participated in the study. Among 26(13%) of infertile males with history of
mumps after puberty 16 infertile which represents about (61.54%) they have
abnormal seminal fluid analysis. Anti-spermanti-bodies was positive in the
serum of 12(46.15%) males out of 26 males with history of mumps after puberty
and Anti sperm antibodies found in the semen of 18(54.55%) males with history
of mumps infection after puberty. Conclusions:Mumps can cause infertility in
male if they infected after puberty due to the rupture of testis blood barrier
and can affect the sperms either by decreasing the count or motility so it can
lead to oligozoospermia or asthenozoospermia, mumps also canlead to production
of antibodies against sperm and can be detected either in blood or seminal
fluid and these antibodies mostly it affect the motility of sperm in the
seminal fluid or the movement of sperm in female reproductive canal and this
result in infertility. - See more at:
No comments:
Post a Comment