Background & objectives- It has been well
established that berberine extracts has strong anti- microbial effects. So,
this study was conducted to evaluate the efficacy of berberine gel as local
drug delivery agent for treatment of pockets in chronic periodontitis through
clinical assessment. Materials & methods- A split-mouth designed study was
conducted in 20 patients having bilateral mild to moderate periodontal pockets
(5-7mm) clinically with radiographic evidence of bone loss. -Following clinical
parameters are recorded on day 0, 7 & 21. i. Gingival Bleeding Index Ii.
Probing Pocket Depth Iii. Clinical Attachment Level Test group (10 patients)
?After scaling and root planing, 1 ml of 5% berberine gel placed into the
selected sites on day 0,day 7 & day 14.Control group (10 patients) - Scaling
and root planingonly. Results:- There was a statistically significant
difference in the gingival bleeding index on both intra-group & inter-group
comparisons on day 21 .Periodontal pocket depth reduction was significant in
intra-group comparison but inter-group comparisons was not significant. The
changes of clinical attachment level was not significant in both intra-group
& inter-group comparisons. Conclusion:- The use of 5% berberine gel
resulted in more clinical improvements when compared to control group, but it
was not considered as a significant benefit. It may be possible that by
increasing the concentration of the berberine drug in the gel, its
sustainability & its evaluation with increased sample size ,significant
effects can be observed. - See more at:
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